Experts believe that by increasing the availability of serotonin, Zoloft and other SSRIs can affect other hormones, including the hormones dopamine and testosterone. Dopamine and testosterone both play key roles in sexual desire and performance. Testosterone erection closely associated with sexual arousal, while dopamine plays an important role in orgasm and ejaculation. Put simply, SSRIs may cause erectile dysfunction and other sexual side effects by affecting the specific hormones and neurotransmitters that Tadalafil tablets you feel aroused and allow you to perform sexually, normal erection. Stopping Zoloft suddenly or reducing your dosage without warning could cause you to develop antidepressant withdrawal symptoms. These can develop within a few days and can range from physical issues like dizziness and flu-like symptoms to anxiety. Before making any changes, talk to your healthcare provider. To treat erectile dysfunction and other sexual side effects, symptoms may recommend that you:. Just like other SSRIs, Zoloft sertraline can and often does cause sexual side effects, including erectile dysfunction.